Fig. 2

Mutational processes of somatic SNVs in IBCs. A Proportions of base substitutions with respect to single-nucleotide-mutation contexts in IBCs and non-IBCs. B Similar to A but with respect to tri-nucleotide mutation contexts. C Proportions of the most represented COSMIC mutational signatures in the whole population age-related: signature 1; homologous recombination deficiency HRD: signature 3; APOBEC activation: signatures 2 and 13; mismatch repair: signatures 6, 20 and 26; POLE: signature 10). The signatures, IHC-based molecular subtypes and IBC/non-IBC groups are color-coded according to the legend