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Table 3 pH correlation to clinical outcome and adverse events

From: Deciphering the importance of culture pH on CD22 CAR T-cells characteristics

Patient

pH

Clinical response

CRS gradea

IEC-HS

Neurotoxicity

5

Low

–

–

–

–

18

Low

–

–

–

–

11

Low

No

0

No

No

13

Low

No

0

No

No

3

Low

Yes

2

Yes

No

4

Low

Yes

1

No

No

7

Low

Yes

1

Yes

No

8

Low

Yes

1

No

No

12

Low

Yes

1

Yes

No

16

Low

Yes

2

No

Yes

19

Low

Yes

2

Yes

No

20

Low

Yes

1

No

Yes

10

High

–

–

–

–

17

High

–

–

–

–

6

High

No

1

No

No

9

High

No

2

Yes

Yes

14

High

No

1

No

Yes

15

High

No

1

No

No

1

High

Yes

2

Yes

Yes

2

High

Yes

2

Yes

Yes

  1. CRS Cytokine Release Syndrome, IEC-HS Immune-Effector Cell HLH-like syndrome
  2. aCRS graded based on American Society for Transplantation and Cellular Therapy criteria: Lee [28]