Fig. 4
From: Deciphering the importance of culture pH on CD22 CAR T-cells characteristics
Increased pH levels at the harvest did not affect final TNC, fold expansion or gas tension. a Significant changes (p < 0.0001) in extracellular pH were noticed in CD22 CAR T-cell products at the harvest. 9 products were collected with pH values at about 7.1 and 11 with pH 7.3. Different pH values at the harvest did not affect final TNC levels (b), fold expansion (c), CD3 percentage (d), pCO2 (e), or pO2 (f). High pH was correlated with significantly upregulated glucose levels (p < 0.0003) (g) and negatively with lactate levels (p < 0.0002) (h)