Fig. 3
From: Deciphering the importance of culture pH on CD22 CAR T-cells characteristics
Elevated levels of selected cytokines and growth factors on Day 2 of the manufacturing process were detected in cell culture supernatants collected at low pH. Lower levels of extracellular pH induced increased secretion of SCF (p < 0.04), M-CSF (p < 0.004), LIF(p < 0.0052), IL-15 (p < 0.0066), IL2Ra (p < 0.0002) and TNF-b (p < 0.0001) into cell culture supernatants compared to the ones cultured in higher pH