Fig. 1

Risk estimates for PCa associated with a 269-PRS in the General-, EO- and LO-population. A Weighted Cox proportional hazard models include all subjects regardless of the family history of PCa. B Weighted Cox proportional hazard models include participants without a family history of PCa. C Weighted Cox proportional hazard models include participants with a family history of PCa. Models were adjusted for age at assessment, BMI, smoking status, drinking status, assessment center and top 10 principal components. General-population covered all participants; EO-population was consisted of individuals with exit-age ≤ 55 years old; LO-population comprised individuals with exit-age > 55 years old. PCa prostate cancer, PRS polygenic risk score, HR hazard ratio, EO early-onset, LO late-onset, SD standard deviation