Fig. 10

Conservations of the three TIDE subtypes in pan-tumors. A Unsupervised hierarchical clustering using the 58 C2 genes to classify pan-tumor samples into three subtypes from TCGA patients (left). K–M analysis shows distinct OS of the TIDE subtypes (right). B The same analysis as A. Unsupervised hierarchical clustering of Pan-cancer samples treated with ICB is shown on the left, and K-M analysis showing distinct OS of the TIDE subtypes is on the right. C Hypergeometric test collaborates an association of pan-tumor TIDE subtypes with ICB therapy responses. Gray lines represent no significance. D Submap analysis reflects the sensitivity of the pan-tumor TIDE subtypes to the targeted treatments