Fig. 2

Genetically predicted circulating proteins in relation to CHD and MI risk. MR volcano plots of plasma proteins versus risk of (a) CHD and (b) MI. (a) and (b) show MR analyses of plasma proteins on CHD and MI risk using Wald ratios or IVW, respectively. OR for increased risk of CHD or MI were expressed as per SD increase in plasma protein levels. Forest plot results of circulating proteins in the discovery and replication phases in relation to (c) CHD and (d) MI risk. OR are scaled to per one SD increase in the genetically predicted circulating proteins levels. Color differences represent different data sets. *, P < 0.05, **, P < 0.01, ***, P < 0.001