Fig. 7
From: Nicotine restores olfactory function by activation of prok2R/Akt/FoxO3a axis in Parkinson’s disease
Prok2R+ HEK293T cells alleviate MPP+-induced apoptosis through the preservation of prok2R/Akt/FoxO3a axis activity. The activity of prok2R/Akt/FoxO3a in different treatment groups (prok2Rvector, prok2Rvector + MPP+, prok2R+, prok2R+ + MPP+) revealed using the western blot (WB) assay (a–d). Apoptosis-related proteins indicated using the WB assay (e–h). Confocal laser scanning microscopy images of Cy3-labeled Cl-casp3 in each group (i, j). Scale bar = 10 μm. Significant differences are shown by *p < 0.05, **p < 0.01, ***p < 0.001. n = 3 in each group