Integrated lipid metabolomics and proteomics analysis reveal the pathogenesis of polycystic ovary syndrome

Qian, Yu; Tong, Yun; Zeng, Yaqiong; Huang, Jingyu; Liu, Kailu; Xie, Ying; Chen, Juan; Gao, Mengya; Liu, Li; Zhao, Juan; Hong, Yanli; Nie, Xiaowei

doi:10.1186/s12967-024-05167-x

Journal of Translational Medicine

Table 2 List of the 144 differential expressed proteins in PCOS patients’ GCs

From: Integrated lipid metabolomics and proteomics analysis reveal the pathogenesis of polycystic ovary syndrome

protein	gene	gene_id	Ctrl	PCOS	FC	log2FC	p.value	adj.Pval
Q15526	SURF1	6834	284,185	173,470	− 1.64	− 0.71	0.000	0.002
Q9Y2Q3	GSTK1	373,156	1,174,341	641,119	− 1.83	− 0.87	0.000	0.003
O43676	NDUFB3	4709	400,938	238,907	− 1.68	− 0.75	0.000	0.003
Q12913	PTPRJ	5795	119,016	42,470	− 2.80	− 1.49	0.000	0.003
O95298	NDUFC2	4718	619,014	357,023	-1.73	-0.79	0.000	0.003
P09488	GSTM1	2944	1,718,348	1,042,070	-1.65	-0.72	0.000	0.003
P63218	GNG5	2787	1,576,490	763,188	− 2.07	− 1.05	0.000	0.003
O75251	NDUFS7	374,291	1,374,515	742,538	− 1.85	− 0.89	0.000	0.003
P02790	HPX	3263	4,250,366	6,880,411	1.62	0.69	0.000	0.003
P25311	AZGP1	563	751,209	1,195,863	1.59	0.67	0.000	0.003
P30837	ALDH1B1	219	2,173,243	1,349,944	− 1.61	− -0.69	0.000	0.003
Q00266	MAT1A	4143	230,553	351,976	1.53	0.61	0.000	0.003
O14949	UQCRQ	27,089	803,205	488,817	− 1.64	− 0.72	0.000	0.003
P02774	GC	2638	3,965,445	5,962,874	1.50	0.59	0.000	0.003
P00738	HP	3240	7,379,939	13,645,033	1.85	0.89	0.000	0.003
P04217	A1BG	1	1,406,796	2,258,651	1.61	0.68	0.000	0.003
Q96PQ0	SORCS2	57,537	384,503	597,165	1.55	0.64	0.000	0.003
P01889	HLA-B	3106	667,757	380,852	− 1.75	− 0.81	0.000	0.003
Q9UKD2	MRTO4	51,154	1,137,548	716,754	− 1.59	− 0.67	0.000	0.003
P51398	DAP3	7818	280,057	186,622	− 1.50	− 0.59	0.000	0.003
P0DPK3	NOTCH2NLB	-	37,072	96,710	2.61	1.38	0.000	0.003
P29508	SERPINB3	6317	310,452	104,771	− 2.96	− 1.57	0.000	0.003
Q9NR31	SAR1A	56,681	3,426,034	2,244,801	− 1.53	− 0.61	0.000	0.003
Q9HD33	MRPL47	57,129	188,825	111,188	− 1.70	− 0.76	0.000	0.003
P04259	KRT6B	3854	540,222	128,236	− 4.21	− 2.07	0.000	0.003
P28161	GSTM2	2946	137,780	72,088	− 1.91	− 0.93	0.000	0.003
P03923	MT-ND6	4541	35,932	20,316	− 1.77	− 0.82	0.000	0.003
Q9H0C2	SLC25A31	83,447	245,346	384,926	1.57	0.65	0.000	0.003
P37235	HPCAL1	3241	361,566	229,922	− 1.57	− 0.65	0.000	0.004
P62834	RAP1A	5906	233,369	153,846	− 1.52	− 0.60	0.000	0.004
O75339	CILP	8483	131,477	209,256	1.59	0.67	0.000	0.004
Q9GZT4	SRR	63,826	136,695	78,395	-1.74	-0.80	0.000	0.004
O60239	SH3BP5	9467	447,227	679,200	1.52	0.60	0.000	0.004
P11511	CYP19A1	1588	9,173,743	18,579,304	2.03	1.02	0.000	0.004
P08514	ITGA2B	3674	215,393	333,968	1.55	0.63	0.000	0.004
P53701	HCCS	3052	338,315	213,073	− 1.59	− 0.67	0.000	0.004
Q96NB2	SFXN2	118,980	79,746	48,362	− 1.65	− 0.72	0.000	0.004
Q9H9B4	SFXN1	94,081	1,452,170	896,065	− 1.62	− 0.70	0.000	0.005
O95810	CAVIN2	8436	66,812	104,678	1.57	0.65	0.000	0.005
Q9H936	SLC25A22	79,751	897,701	589,248	− 1.52	− 0.61	0.000	0.005
Q9P032	NDUFAF4	29,078	1,149,556	702,973	− 1.64	− 0.71	0.000	0.005
P33947	KDELR2	11,014	296,115	183,010	− 1.62	− 0.69	0.000	0.005
Q9Y250	LZTS1	11,178	263,805	149,676	− 1.76	− 0.82	0.000	0.005
Q14134	TRIM29	23,650	284,192	100,645	− 2.82	− 1.50	0.000	0.005
Q92954	PRG4	10,216	74,379	122,829	1.65	0.72	0.000	0.005
P08567	PLEK	5341	334,199	536,897	1.61	0.68	0.000	0.005
P01911	HLA-DRB1	3123	228,205	141,967	− 1.61	− 0.68	0.000	0.006
P12273	PIP	5304	25,201	5,741	− 4.39	− 2.13	0.000	0.006
P29373	CRABP2	1382	157,270	81,808	− 1.92	− 0.94	0.000	0.006
Q96BW9	TAMM41	132,001	55,221	16,690	− 3.31	− 1.73	0.000	0.006
Q8NGY0	OR10X1	128,367	108,409	19,110	− 5.67	− 2.50	0.000	0.006
Q9NQ66	PLCB1	23,236	218,829	121,685	− 1.80	− 0.85	0.000	0.006
Q9UDW1	UQCR10	29,796	236,050	124,516	− 1.90	− 0.92	0.000	0.006
O75964	ATP5MG	10,632	1,037,671	627,542	− 1.65	− 0.73	0.000	0.006
Q8IYA8	IHO1	339,834	219,200	47,890	− 4.58	− 2.19	0.000	0.006
Q96C55	ZNF524	147,807	19,907	32,877	1.65	0.72	0.000	0.006
P62244	RPS15A	6210	8,620,369	5,315,558	− 1.62	− 0.70	0.000	0.006
P02750	LRG1	116,844	502,437	764,431	1.52	0.61	0.000	0.007
P14923	JUP	3728	699,684	355,553	− 1.97	− 0.98	0.000	0.007
O94788	ALDH1A2	8854	221,934	142,853	− 1.55	− 0.64	0.000	0.007
Q9Y3D7	PAM16	51,025	711,534	315,270	− 2.26	− 1.17	0.000	0.007
Q9BXY0	MAK16	84,549	35,784	18,624	− 1.92	− 0.94	0.000	0.008
Q9BUR5	APOO	79,135	667,855	353,501	− 1.89	− 0.92	0.000	0.008
O95707	POP4	10,775	14,068	5,052	− 2.78	− 1.48	0.000	0.008
P00167	CYB5A	1528	1,282,803	735,534	− 1.74	− 0.80	0.001	0.008
Q9Y2Z4	YARS2	51,067	241,251	155,613	− 1.55	− 0.63	0.001	0.008
O95388	CCN4	8840	51,952	83,724	1.61	0.69	0.001	0.008
Q14CS0	UBXN2B	137,886	31,015	47,772	1.54	0.62	0.001	0.009
P46782	RPS5	6193	4,392,982	2,690,597	− 1.63	− 0.71	0.001	0.009
P17152	TMEM11	8834	642,886	416,122	− 1.54	− 0.63	0.001	0.009
P02795	MT2A	4502	19,503,859	29,591,086	1.52	0.60	0.001	0.009
Q9Y241	HIGD1A	25,994	169,400	101,036	− 1.68	− 0.75	0.001	0.009
P10909	CLU	1191	4,548,982	7,925,039	1.74	0.80	0.001	0.009
O00534	VWA5A	4013	9,880	16,060	1.63	0.70	0.001	0.009
Q9BTY2	FUCA2	2519	81,811	51,213	− 1.60	− 0.68	0.001	0.009
P19256	CD58	965	29,751	17,925	− 1.66	− 0.73	0.001	0.010
Q9GZT6	CCDC90B	60,492	51,309	23,390	− 2.19	− 1.13	0.001	0.010
P69892	HBG2	3048	120,179	70,954	− 1.69	− 0.76	0.001	0.010
O75438	NDUFB1	4707	223,826	139,189	− 1.61	− 0.69	0.001	0.010
Q96IX5	ATP5MK	84,833	360,976	208,888	− 1.73	− 0.79	0.001	0.010
P15880	RPS2	6187	6,348,391	3,722,541	− 1.71	− 0.77	0.001	0.010
P02654	APOC1	341	860,143	466,404	− 1.84	− 0.88	0.001	0.010
Q9UBG3	CRNN	49,860	76,918	24,136	− 3.19	− 1.67	0.001	0.011
P46781	RPS9	6203	5,215,220	2,227,525	− 2.34	− 1.23	0.001	0.011
P06703	S100A6	6277	1,201,162	771,837	− 1.56	− 0.64	0.001	0.012
Q8N4H5	TOMM5	401,505	1,142,248	738,886	− 1.55	− 0.63	0.001	0.012
P82930	MRPS34	65,993	121,804	65,432	− 1.86	− 0.90	0.001	0.012
P53675	CLTCL1	8218	87,078	58,043	− 1.50	− 0.59	0.001	0.012
Q5VW38	GPR107	57,720	485,922	746,582	1.54	0.62	0.001	0.012
Q5VW32	BROX	148,362	577,561	372,850	− 1.55	− 0.63	0.002	0.013
Q6DKI1	RPL7L1	285,855	149,708	70,407	− 2.13	− 1.09	0.002	0.014
P02766	TTR	7276	238,544	383,317	1.61	0.68	0.002	0.015
Q8TF42	UBASH3B	84,959	143,903	219,528	1.53	0.61	0.002	0.015
P32969	RPL9	6133	5,202,187	3,095,939	− 1.68	− 0.75	0.002	0.015
O43677	NDUFC1	4717	60,106	28,897	− 2.08	− 1.06	0.002	0.015
Q6P2S7	TTC41P	–	603,584	365,283	− 1.65	− 0.72	0.002	0.016
Q30154	HLA-DRB5	3127	44,004	11,147	− 3.95	− 1.98	0.002	0.016
Q86VV8	RTTN	25,914	311,361	196,196	− 1.59	− 0.67	0.002	0.016
P00403	MT-CO2	4513	1,399,412	886,732	− 1.58	− 0.66	0.002	0.017
Q9BRU2	TCEAL7	56,849	20,218	32,996	1.63	0.71	0.003	0.017
O96015	DNAL4	10,126	21,608	12,550	− 1.72	− 0.78	0.003	0.017
Q9UM19	HPCAL4	51,440	76,954	36,512	− 2.11	− 1.08	0.003	0.018
Q9UMX5	NENF	29,937	339,207	222,907	− 1.52	− 0.61	0.003	0.019
Q5VWG9	TAF3	83,860	11,725	18,826	1.61	0.68	0.003	0.019
Q8N442	GUF1	60,558	75,978	48,778	− 1.56	− 0.64	0.003	0.019
Q4KMQ1	TPRN	286,262	5,816	9,197	1.58	0.66	0.003	0.020
Q9Y5U9	IER3IP1	51,124	113,646	61,235	− 1.86	− 0.89	0.003	0.020
Q5U3C3	TMEM164	84,187	44,863	25,819	− 1.74	− 0.80	0.004	0.021
Q5TGZ0	MICOS10	440,574	743,045	390,926	− 1.90	− 0.93	0.005	0.026
Q96ND0	FAM210A	125,228	282,317	179,501	− 1.57	− 0.65	0.005	0.026
Q96I45	TMEM141	85,014	115,039	70,544	− 1.63	− 0.71	0.006	0.027
Q6S8J3	POTEE	445,582	493,731	167,770	− 2.94	− 1.56	0.006	0.027
Q86SE9	PCGF5	84,333	22,535	40,089	1.78	0.83	0.006	0.029
Q969U7	PSMG2	56,984	326,118	183,555	− 1.78	− 0.83	0.007	0.030
Q8NI22	MCFD2	90,411	87,857	55,515	− 1.58	− 0.66	0.007	0.031
P63167	DYNLL1	8655	2,081,999	1,351,996	− 1.54	− 0.62	0.009	0.035
P07108	DBI	1622	1,989,043	1,183,131	− 1.68	− 0.75	0.010	0.036
Q96EX1	SMIM12	113,444	85,648	29,536	− 2.90	− 1.54	0.012	0.040
P04080	CSTB	1476	509,128	312,837	− 1.63	− 0.70	0.012	0.041
Q9NX55	HYPK	25,764	89,531	136,144	1.52	0.60	0.012	0.041
P15954	COX7C	1350	1,061,237	619,515	− 1.71	− 0.78	0.012	0.042
Q9NX47	MARCHF5	54,708	50,287	31,896	− 1.58	− 0.66	0.015	0.046
Q15528	MED22	6837	610,344	405,677	− 1.50	− 0.59	0.016	0.049
P60602	ROMO1	140,823	118,431	78,365	− 1.51	− 0.60	0.016	0.049
P62805	H4C1	121,504	62,707,994	29,548,173	− 2.12	− 1.09	0.017	0.052
P20962	PTMS	5763	926,341	1,462,639	1.58	0.66	0.018	0.053
P54727	RAD23B	5887	2,645,799	1,703,085	− 1.55	− 0.64	0.019	0.054
Q13405	MRPL49	740	42,753	28,458	− 1.50	− 0.59	0.020	0.056
P00739	HPR	3250	5,937	10,998	1.85	0.89	0.020	0.057
Q15329	E2F5	1875	56,906	205,274	3.61	1.85	0.020	0.057
Q96MR6	CFAP57	149,465	32,510	49,101	1.51	0.59	0.022	0.061
Q99653	CHP1	11,261	688,597	422,414	− 1.63	− 0.71	0.023	0.062
O00483	NDUFA4	4697	2,330,413	1,102,940	− 2.11	− 1.08	0.024	0.064
O15069	NACAD	23,148	3,683	5,718	1.55	0.63	0.024	0.064
P50150	GNG4	2786	12,654	8,096	− 1.56	− 0.64	0.024	0.064
Q13835	PKP1	5317	739,970	221,000	− 3.35	− 1.74	0.024	0.064
O00292	LEFTY2	7044	1,667	3,516	2.11	1.08	0.025	0.066
Q96A72	MAGOHB	55,110	2,809,579	1,841,289	− 1.53	− 0.61	0.025	0.067
Q9NZD4	AHSP	51,327	75,582	37,533	− 2.01	− 1.01	0.028	0.072
Q14191	WRN	7486	230,368	558,126	2.42	1.28	0.029	0.073
P30536	TSPO	706	611,183	340,994	− 1.79	− 0.84	0.032	0.077
Q02413	DSG1	1828	154,954	67,828	− 2.28	− 1.19	0.040	0.090
O60437	PPL	5493	891,734	589,101	− 1.51	− 0.60	0.048	0.102
Q8NC42	RNF149	284,996	51,948	84,835	1.63	0.71	0.049	0.105

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