Fig. 2

The GR encoded by the NR3C1 gene is predicted to regulate PRNP gene expression in human CRC. A–C Analysis of the GSE8671 (A) GSE20916 (B) and GSE4183 (C) datasets reveals decreased PRNP expression across the normal to adenoma sequence, followed by an increase from the adenoma to carcinoma sequence in human CRC. D Schematic representation of the selection of ETS1 and NR3C1 as candidate transcription factors regulating the expression of PRNP in human CRC. E Scatter plot showing the correlation between PRNP and NR3C1 mRNA levels in the GSE39582 dataset of human CRC. F Predicted NR3C1 binding sites within the human PRNP gene promoter. G Relative NR3C1 mRNA levels according to the CMS classification in the GSE39582 dataset of human CRC. NT = non tumor. H–J Analysis of the GSE8671 (H) GSE20916 (I) and GSE4183 (J) datasets reveals decreased NR3C1 expression across the normal to adenoma sequence, followed by an increase from the adenoma to carcinoma sequence in human CRC. K–M Scatter plots showing the correlation between PRNP and NR3C1 mRNA levels in GSE8671 (K) GSE20916 (L) and GSE4183 (M) datasets