Fig. 6
From: Edge-based relative entropy as a sensitive indicator of critical transitions in biological systems
The regulatory mechanism of cancer development revealed by ERE signaling gene pairs. KEGG pathway enrichment analysis for the ERE signaling gene pairs of A COAD and B THCA. C Switching dynamics of downstream differential genes before and after the critical state conducted by upstream ERE signaling gene pairs in COAD. Cytokines are coded by IL6, CSF3, and OSM, which correspond to signaling gene pairs after mapping into the PPI network