Fig. 7
From: Discovery of a novel and highly selective JAK3 inhibitor as a potent hair growth promoter
The model shows the fate of hair follicles under alopecia pathogenesis and restoration of growth of hair follicles upon blocking the production of pro-inflammatory cytokines with MJ04 as JAK3 inhibitor. A Shows the healthy hair follicle in the anagen phase of the growth cycle. B Shows the disrupted microenvironment of hair follicles due to infiltration of proinflammatory cytokines and immune cells during alopecia pathogenesis. C Blocking JAK-STAT signaling in immune cells inhibits the production of pro-inflammatory cytokines that restore back homeostasis around hair follicles allowing them to enter into a new growth cycle