Fig. 4

The changes in fecal metabolome between severe preeclampsia and healthy controls, and functional enrichment of differential fecal metabolite features. A PLS-DA plot of fecal metabolite profiles indicates the significant differentiation of fecal metabolite profiles between severe preeclampsia and healthy controls. B Significantly different abundances of fecal metabolites by Random Forest model. C-D KEGG pathways enriched by the metabolite features show higher abundances in f healthy controls (C ) and severe preeclampsia (D ). The X-axis and the size of the dots indicate the pathway impact of altered metabolite features, and the Y-axis shows the P-value obtained for each pathway in the enrichment analysis. The size and color of the dots indicate the overall pathway impact. SPE: severe preeclampsia; Control: healthy controls