Fig. 3

KEGG pathways and KO genes show significant shifts in abundances between severe preeclampsia and healthy controls, and their relationships with differential bacterial species. A Differential KO genes. B Differential KEGG pathways. C The heat maps showing the relationships between differential bacterial species, and differential KEGG pathways and KO genes. The X-axis represents the differential bacterial species. The Y-axis indicates the differential KEGG pathways and KO genes. * P < 0.05, ** P < 0.01, and *** P < 0.001. SPE: severe preeclampsia; Control: healthy controls