Fig. 2

Identification of bacterial species associated with severe preeclampsia based on metagenomic sequencing data. A Bacterial species showing significantly different abundances between severe preeclampsia and healthy controls. LEfSe analysis was used to identify differential bacterial species. LDA score ≥ 2 was set as the threshold. B Bacterial species that could discriminate severe preeclampsia and healthy controls by Random Forest model. C Receiver operating curve (ROC). The AUC was 90.00% with a 95% CI of 70.27–100%. D The abundance of Limosilactobacillus fermentum was confirmed by qPCR. SPE: severe preeclampsia; Control: healthy controls