Fig. 1

CD137⁺ T cell subsets sLAG3, sPDL1, and IL-8 correlated with response to ICIs in 89 NSCLC patients. A The scattered dot plots display the values of CD137⁺ (total, CD8⁺, and CD4⁺) and CD137⁺ PD1⁺ (total, CD8⁺, and CD4⁺) T cells in responder (R) and non-responder (NR) patients. The horizontal lines correspond to the median values of each CD137⁺ T cell subset in the two groups of patients. B The histograms represent the median values of CD137⁺ and CD137⁺ PD1⁺ T cells of patients with partial response (PR, in black), stable disease (SD, in dark grey), and progression (PD, in light grey) ± standard error of the mean (SEM). C The scattered dot plots show the percentage of CD137⁺ T cells (total, CD8⁺, and CD4⁺) in patients treated with immunotherapy as first (I) and second line (II). The horizontal lines correspond to the median values of each CD137⁺ T cell subset in the two groups of patients. D The histograms represent the median values expressed in pg/mL of soluble LAG3, PDL1, and IL8 in R (black histograms) and NR (gray histograms) patients ± SEM. p values < 0.05 were considered significant