Fig. 6

Mechanism of double-negative T cells inhibiting progression against psoriasis. The mechanism of double-negative T cells inhibition progression against psoriasis involved two aspects: cytotoxicity and chemotaxis. In terms of cytotoxicity, within the IMQ-induced psoriasis mouse model, the expression of NKG2D ligands on γδ^low T cells in skin was increased, leading to the selectively cytotoxic effect of DNT on γδ^low T cells. Regarding chemotaxis, within the IMQ-induced psoriasis mouse model, the increased expression of CCR5 ligands in the skin causes the transfer of DNT to the inflammatory skin area