Fig. 2

Construction of MAOS and MAPS signatures in TCGA training set. (A and B) Clinical characteristics of MAOS and MAPS signatures in TCGA COAD cohorts, respectively. T, tumor size and local growth; N, extent of lymph node metastases; M, occurrence of distant metastases in tumor-node-metastasis (TNM) system. MSI, microsatellite instability; LVI, Lymphovascular invasion. (C and D) The distribution of risk score, survival status and gene expression panel in the TCGA training set for MAOS and MAPS, respectively. For each patient, a risk score was calculated based on the prognostic signature, and all patients are displayed (sorted from low to high score). The vertical dotted line indicates the median cutoff dividing patients into low-risk and high-risk groups. (E and F) Kaplan-Meier survival analysis and ROC curve analysis for patients in TCGA training set of MAOS and MAPS, respectively