Fig. 2
From: The interaction of platelet-related factors with tumor cells promotes tumor metastasis
Integrin signaling generated by binding to extracellular matrix (ECM) ligands occurs. In the absence of ligand binding, αvβ3 integrin recruited kras and src to drive cell reprogramming events, which led to phenotypic changes, thus promoting stem dryness, metastasis and drug resistance. Fibrin-fibronection complex induces the activation of αvβ3 integrin, which triggers Survival, prolifera on, adhesion, migra? on, invasion in cancer cells