Fig. 6From: Transcriptome and open chromatin analysis reveals the process of myocardial cell development and key pathogenic target proteins in Long QT syndrome type 7Dynamics of chromatin accessibility during cardiomyocyte differentiation in the mutation and CRISPR groups. A, B Correlation analysis of the RNA-seq data and ATAC-seq data at different stages. The colors represent the Kendall correlation coefficients between samples, which were calculated using FPKM values for gene expression (for RNA-seq) and genome-wide chromatin accessibility (for ATAC-seq). The darker the color is, the higher the correlation. C Changes in overlapping open chromatin regions between different groups of cells and cell lines at different stages. D Motif analysis: matched motifs from the differential peaks in the ATAC-seq data from the mutation and CRISPR groups are shown. E Verification to determine whether the gene expression of the corresponding transcription factor in a specific time period correlates with an open chromatin state. The E-value is the enrichment p-value times the number of candidate motifs testedBack to article page