Table 2 Univariate and multivariate analysis of clinicopathological factors that correlate with OS of LUAD patients

T stage

523

T1&T2

457

Reference

T3&T4

66

2.317 (1.591–3.375)

< 0.001

2.272 (1.119–4.614)

0.023

N stage

510

N0

343

Reference

N1&N2&N3

167

2.601 (1.944–3.480)

< 0.001

1.350 (0.817–2.233)

0.242

M stage

377

M0

352

Reference

M1

25

2.136 (1.248–3.653)

0.006

1.748 (0.663–4.607)

0.259

Gender

526

Female

280

Reference

Male

246

1.070 (0.803–1.426)

0.642

Age

516

<=65

255

Reference

> 65

261

1.223 (0.916–1.635)

0.172

Pathologic stage

518

Stage I&Stage II

411

Reference

Stage III&Stage IV

107

2.664 (1.960–3.621)

< 0.001

1.496 (0.771-2.900)

0.234

Primary therapy outcome

439

PD&SD

108

Reference

PR&CR

331

0.377 (0.268–0.530)

< 0.001

0.369 (0.224–0.606)

< 0.001

Residual tumor

363

R0

347

Reference

R1&R2

16

3.879 (2.169–6.936)

< 0.001

2.998 (1.183–7.597)

0.021

TNFSF11

526

Low

265

Reference

High

261

1.594 (1.191–2.133)

0.002

1.866 (1.171–2.973)

0.009