Fig. 7
Schematic representation of the potential mechanism of propofol in regulating membrane TLR4 expression on macrophages. Rab5a participates in intracellular trafficking of TLR4 between Golgi and cell membrane in macrophages upon LPS treated and propofol reduces membrane TLR4 expression on macrophages by inhibiting Rab5a expression and the interaction between Rab5a and TLR4