Fig. 2

ECP treatment attenuates pathological symptoms in CIA mice. a Ankle joints tissue Sects. (3 μm) were utilized for hematoxylin and eosin (H&E) staining, with representative images from each experimental group. b Representative images of ankle joints tissue sections were utilized for Safranin-O staining. c On day 49, images of live mice paws were captured and used to create 3D reconstructions via micro-computed tomography (micro-CT). d Inflammation and synovial hyperplasia were assessed by H&E staining and cartilage damage was assessed by safranin-O staining with a scoring range of 0 to 4. Data are shown as mean ± SEM. n = 5–6 for each group. *P ≤ 0.05, **P ≤ 0.01, ***P ≤ 0.001, ****P ≤ 0.0001