Fig. 3
From: Potential anti-tumor effects of regulatory T cells in the tumor microenvironment: a review
Spatiotemporal heterogeneity of Tregs function in TME. A In non-inflammatory tumors, Tregs mainly inhibit anti-tumor immunity. Conversely, in inflammatory tumors, Tregs tend to improve prognosis by suppressing tumor-promoting inflammation. B There exist variances in the function of Tregs in the tumor nests as compared to those in the mesenchyme. C As the tumor progressed, TNFRSF9− Tregs transformed into TNFRSF9+ Tregs, leading to a gradual enhancement of their immunosuppressive abilities