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Table 2 List of differential metabolites and lipids between asthmatic and COPD patients

From: An integrated metabo-lipidomics profile of induced sputum for the identification of novel biomarkers in the differential diagnosis of asthma and COPD

Compound

m/z

Rt (s)

VIP-score

Fold changea

P value

Metabolic pathway

Class

PE (34:1)

718.5381

2.77

3.093

0.3050

0.00027

Glycerophospholipids metabolism

GPE

Spermine

203.2230

0.61

3.176

0.3506

0.0005

Arginine and proline metabolism

Polyamines

PG (18:1;18:2)

771.5182

3.11

3.003

0.2591

0.0009

Glycerophospholipids metabolism

GPG

Putrescine

89.1075

0.63

3.255

0.3538

0.001

Arginine and proline metabolism,

Polyamines

PC (33:0)

748.5851

3.01

2.181

0.2313

0.002

Glycerophospholipids metabolism

GPC

6-Hydroxykynurenic acid

206.0446

1.80

2.055

0.4704

0.006

Tryptophan metabolism

organic acid

PG (18:1;18:1)

792.5749

2.74

2.493

0.3214

0.009

Glycerophospholipids metabolism

GPG

AcCa (4:0) (butyryl-l-carnitine)

232.1543

0.25

2.879

1.8228

0.011

Energy metabolism

Fatty acyl carnitines

PG (16:1;18:1)

745.5025

3.09

2.538

0.4165

0.014

Glycerophospholipids metabolism

GPG

Hexanoic acid (caproate)

115.0765

1.82

1.517

0.5338

0.02

Fatty Acid Biosynthesis

Fatty Acids and Conjugates

PE (36:3)

742.5381

2.86

2.541

0.3594

0.02

Glycerophospholipids metabolism

GPE

l-Lysine

147.1128

0.60

2.138

2.2831

0.03

Amino acid metabolism biotin metabolism

Amino acids

d-Rhamnose

163.0612

0.67

1.630

2.0597

0.03

ABC transporters

Deoxy sugars

LPE (18:1)

480.3085

1.76

2.400

0.6184

0.03

Glycerophospholipids metabolism

GPE

Pentanoate (valerate)

101.0608

0.72

1.400

0.5109

0.03

Fatty acid biosynthesis

Fatty Acids and Conjugates

LPE (O-18:2)

462.2990

2.52

1.943

0.5329

0.03

Glycerophospholipids metabolism

GPE

LPG (18:1)

509.2885

2.22

2.149

0.4407

0.03

Glycerophospholipids metabolism

GPG

PC (32:2)

730.5381

2.76

1.986

0.3967

0.04

Glycerophospholipids metabolism

GPC

Phosphate

96.9696

0.62

2.789

0.5913

0.04

Aspartate metabolism

Inorganic compounds

Cer (d18:1;16:0)

520.5088

3.03

2.372

1.6972

0.04

Sphingolipid metabolism

Cer

PC (38:3)

812.6163

3.05

1.817

0.3620

0.04

Glycerophospholipids metabolism

GPC

SM (d32:1)

675.5435

2.65

2.286

0.5341

0.046

Sphingolipid metabolism

SM

  1. aFold change value refers to the “COPD versus ASTHMA” change values
  2. m/z mass-to-charge ratio, Rt retention time, VIP variance importance for projection, PE Phosphatidylethanolamine, GPE glycerophosphoethanolamines, LPE Lysophosphatidylethanolamine, LPG Lysophosphatidylglycerol, GPG glycerylphosphorylglycerols, PC Phosphatidylcholine, GPC glycerophosphatidylcholine, Cer ceramides, SM sphingomyelins
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Journal of Translational Medicine

ISSN: 1479-5876

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