Outcome | No. (1) | No. (2) | Cochran’s Q test | MR-Egger intercept test | MR-PRESSO | HEIDI test |
---|
Q statistic | P-value | Intercept | P-value | P-value of global test | P-value | nSNP |
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DR | 921 | 17 | 14.26 | 0.58 | 0.023 | 0.23 | 0.66 | 0.59 | 20 |
NPDR | 17 | 5.54 | 0.99 | 0.023 | 0.44 | 0.99 | 0.46 | 20 |
PDR | 17 | 18.58 | 0.29 | 0.044 | 0.28 | 0.36 | 0.31 | 20 |
- DR: Diabetic retinopathy; NPDR: Non-proliferative diabetic retinopathy; PDR: Proliferative diabetic retinopathy; No. (1): Numbers of eligible cis-eQTLs (expression quantitative trait loci studies) of HMGCR (3-hydroxy-3-methylglutaryl-coenzyme A reductase); No. (2): Numbers of genetic instruments not containing palindromic sequences or not being the outliers. MR: Mendelian randomization; MR-PRESSO: Mendelian randomization pleiotropy residual sum and outlier; HEIDI: Heterogeneity in dependent instruments, nSNP: Numbers of single nucleotide polymorphism