Fig. 1
From: The epitome of tailor-made short positively charged peptides against HCC via integrated pharmacology
A The mining workflow of short positively charged peptides (SPCPs) of this study. B The number of 244 targets between SEA and STP. C The final 136 targets for the analysis. D The protein–protein interaction (PPI) networks. E The 16 signaling pathways related to hepatocellular carcinoma. F The number of 6 intersecting SPCPs in 5 key targets from SEA. G The number of 7 intersecting SPCPs in 5 key targets from STP. H The SPCPs-targets-signaling pathway (STS) networks. A: Alanine; F: Phenylalanine; H: Histidine; K: Lysine; S: Serine; T: Threonine; V: Valine. I The docking scores on 2 SPCPs (KFAH, and HFAK)-5 key targets (CTSB, CASP1, BIRC3, XIAP, and CASP8) via HPEPDOCK 2.0. Blue rectangles: the most significant conformers on SPCPs-key targets. J The CA-074—CTSB conformer via AutoDock. K The Belnacasan—CASP1 conformer via AutoDock. L The GDC-0152—BIRC3 conformer via AutoDock. M The GDC-0152—XIAP conformer via AutoDock. N The Z-IETD-FMK—CASP8 conformer via AutoDock. O The comparison of energy gap between two key SPCPs and standard compounds