Fig. 2

COMP binds to ovarian cancer cells and enhances their migration and invasion. A The binding ability of purified recombinant COMP to the surfaces of SKOV3 and OAW42 cells was evaluated by flow cytometry. Each concentration was compared with untreated cells as a control. Geometric mean fluorescence intensity: gMFI. The effect of increasing concentrations of COMP on SKOV3 and OAW42 on cell migration B and D and invasion C and E was assessed using transwell assays. The p-value was calculated by one-way ANOVA followed by Dunnett’s post-test. Data are representative of at least three independent experiments and graphs depict the mean with the standard deviation. Scale bar: 100 µm. P < 0.05 was considered statistically significant. (*, **, ***, ****, and ns indicate p < 0.05, p < 0.01, p < 0.001, p < 0.0001, and non-significant, respectively)