Fig. 4

The proportion of T cell subsets in PI16^CKO and PI16^fl/fl AIA mice. The expression level of Th1 (A, 1.62 ± 0.25% vs. 1.61 ± 0.19%, p = 0.968), Th2 (B, 1.15 ± 0.13% vs. 1.22 ± 0.13%, p = 0.727), Th17 (C, 1.00 ± 0.12% vs. 3.84 ± 0.64%, p = 0.001), and Treg (D, 1.46 ± 0.14% vs. 0.64 ± 0.07%, p < 0.0001) in AIA model mice; E, F Th17/Treg balance (E, 0.71 ± 0.06% vs. 8.07 ± 1.98%, p = 0.003) and Th1/Th2 balance (F, 1.71 ± 0.43% vs. 1.51 ± 0.27%, p = 0.018) in AIA model mice. (PI16^CKO AIA = 10, PI16^fl/fl AIA = 10, PI16^CKO NC = 3, PI16^fl/fl NC = 3) *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001