Fig. 3
Mice with Treg cell-specific PI16 ablation are protected from autoimmune arthritis. A Diagram for the induction of AIA model; B severity of arthritis in AIA mice (n = 6) was evaluated by determining the diameter of the knee joint from the 21st day after the third immunization (n = 5); C representative images showed the H&E analysis for histopathological changes PI16CKO or PI16fl/fl mice (n = 4) (The magnification of the first and third line is 40×; the magnification of the second and fourth line is 100×)