Fig. 2

PI16-deficiency in Treg enhances the suppressive functions of Tregs. Mitomycin-treated CD4⁺ cells (APC) and CD4⁺CD25⁻ effective T cells were cocultured with Tregs that sorted from PI16^CKO or PI16^fl/fl mice (n = 3) at different Treg/Teff ratios (0:1, 1:1, 1:2, 1:4, 1:8). ns: p > 0.05, *p < 0.05