Fig. 5

Identifying key cell types in the acute pathogenesis of HLA-B27 positive spondyloarthritis complicating anterior uveitis. A Clustering projection according to Seurat’s clustering system using UMAP as the dimension reduction method. B Box plots of expression levels of AIF1 across different cell types in both the HLA-B27-negative and HLA-B27-positive groups. *P < 0.05; ****P < 0.0001. C Dimensional reduction plot displaying the expression patterns of AIF1 in both the HLA-B27-negative and HLA-B27-positive groups. D Stacked chart of the proportions of different cell types within the HLA-B27-negative and HLA-B27-positive groups. E Box plots of the difference in the proportions of high AIF-expressing cell types between the HLA-B27-negative and HLA-B27-positive groups. F Heatmap of the activation of transcription factors across various cell types in the HLA-B27-positive group