Multi-omics analysis of the gut microbiome and metabolites associated with the psychoneurological symptom cluster in children with cancer receiving chemotherapy

Table 4 Gut microbiome associated with the node of metabolome-psychoneurological symptom cluster

Study group	Symptom cluster	Gut microbial genera
Children with cancer at T₀	Cluster 5	Ruminococcus, Parasutterella
Children with cancer at T₀	Cluster 6	Parabacteroides, Veillonella, Megasphaera, UBA1819, Escherichia–Shigella, Prevotella
Children with cancer at T₁	Cluster 4	Megasphaera
Healthy controls	Cluster 5	Lachnoclostridium, UBA1819, Coprococcus, Prevotella, Alistipes
Healthy controls	Cluster 6	Anaerostipes, Phascolarctobacterium

T₀: pre-cycle two chemotherapy; T₁: post chemotherapy (completion of all chemotherapy)

ISSN: 1479-5876