Fig. 6

Predictive power of cross-sectional reactivity of HBV-specific T cells for hepatitis progression in CHB patients. CHB patients were divided into normal (ALT < 40 IU/L) group and abnormal (ALT > 40 IU/L) group of liver function at the test time of HBV-specific T cells or 6 months later after the test. ROC curve analyses of DNA load (IU/mL), HBV-specific T cells (SFUs/2 × 10⁵ PBMCs), and a combination were performed to predict hepatitis progression at the test time of HBV-specific T cells (A) and 6 months later after the test (B), using R package pROC, and summarized in table. ROC, receiver operating characteristic; AUC, area under the curve; PPV, positive predictive value; NPV, negative predictive value. The p¹ values represent the significance of model. The p² values represent the significance of difference between the AUC of combined markers (DNA load + Specific T cell) and single predictor