Fig. 5

Dynamic changes of sero-virological parameters during different fluctuation courses of HBV-specific T cells. 33 CHB patients were followed by HBV-specific T cell detection and sero-virological parameters collections for three times at an interval of 3–5 months. According to the dynamic courses of HBV-specific T cells (SFUs), patients were categorized as ascending (A), ascending/descending (B), stationary, descending, or descending/ascending groups, then HBV DNA load, HBsAg, HBeAg, HBx, HBpol and ALT levels were longitudinally analyzed. The SFU numbers of reactive HBV-specific T cells which increased or decreased more than 50% than last test were defined as ascending or descending during the follow-up period