Fig. 10From: Single-cell transcriptomic sequencing data reveal aberrant DNA methylation in SMAD3 promoter region in tumor-associated fibroblasts affecting molecular mechanism of radiosensitivity in non-small cell lung cancerThe mechanism graph of the regulatory network and function of SMAD3 in radioresistance of NSCLC. SMAD3 is significantly enriched in CAFs, which may promote the radioresistance of NSCLC cells by activating the ITGA6/PI3K/Akt pathwayBack to article page