Fig. 5

PLA2G4A, PLA2G3, DGKA, ACHE, and CHKA may be potential targets for regulating endogenous lipids in platin-resistant GC patients. A Distribution of Platinum resistance and Glycerophospholipid metabolism target genes. B Protein–protein interaction (PPI) network revealed the interaction of PLA2G4A, PLA2G3, DGKA, ACHE, and CHKA. C Lipid metabolite-reaction-enzyme-gene network. The red hexagons represent the detected lipids and other metabolite biomarkers in our study. Pink hexagons represent metabolites participating in the same metabolic pathway but were not detected in our study. The dark green diamonds represent the metabolic reaction of the compound. The green squares represent the enzyme. The purple circle represents genes