Fig. 9

IDO1 inhibitor suppressed endothelial mitophagy and effectively inhibited ovarian cancer progression. a Representative images of the primary ovary tumor size in orthotopic OC model education with the ctrl (control) or IDO1 inhibitor. bar = 1 cm. (n = 5, Mean ± SD, t-test, ***P < 0.001). b Numbers of peritoneal metastases confirmed by HE staining in orthotopic OC model treated with ctrl or IDO1 inhibitor. Scale bar:50 μm. (n = 5, Mean ± SD, t-test, *P < 0.05). c Immunohistochemistry (IHC) analysis of CD31 in primary tumor tissues of orthotopic OC model education with the ctrl or IDO1 inhibitor. Scale bar:50 μm. (n = 3, Mean ± SD, t-test, **P < 0.01). d Representative images of LC3, TOMM20, and CD31 in primary tumor tissue sections of orthotopic OC model treated with the ctrl or IDO1 inhibitor by immunofluorescence staining. Scale bar:20 μm