Fig. 5

WIF1 overexpression normalizes retina histology in db/db mice. A TEM images depicting cytopyknosis (arrow) observed in the inner nuclear layer of db/db mice retina across various groups: (a) db/m, (b) db/db, (c) control, and (d) WIF1. B TEM images illustrating the presence of mitochondria (arrow) and photoreceptor synaptic ribbons (triangle) within the outer plexiform layer (OPL) of four groups: (a) db/m, (b) db/db, (c) control, and (d) WIF1. C TEM images showcasing autophagosomes (pentagram) and cytopyknosis (arrow) within the outer nuclear layer (ONL) of different groups: (a) db/m, (b) db/db, (c) control, and (d) WIF1. D TEM images displaying endoplasmic reticulum (triangle) and mitochondria (arrow) within various groups: (a) db/m, (b) db/db, (c) control, and (d) WIF1. E TEM images reveal Golgi structures (pentagram) and mitochondria (arrow) in photoreceptors within different groups: (a) db/m, (b) db/db, (c) control, and (d) WIF1. F TEM images highlighting photoreceptor outer segments (OS) (arrow) in diverse groups: (a) normal, (b) db/db, (c) control, and (d) WIF1. The presented data depict the average and standard deviation from a minimum of three repetitions, with differences assessed using standard one-way ANOVA. *p < 0.05, **p < 0.01, ***p < 0.001