Fig. 4
From: WNT-inhibitory factor 1-mediated glycolysis protects photoreceptor cells in diabetic retinopathy
WIF 1 inhibits glycolysis and improves photoreceptor function in db/db mice. A Western blot and quantification of retinal protein levels in the db/m, db/db, control, and WIF1 groups. B qRT-PCR analysis of the WIF1 mRNA decreased in db/db mice treated with LV-WIF1. C Levels of secreted lactate in db/db mouse retinas. D Flow cytometric analysis was employed to detect reactive oxygen species (ROS) within the retinas of the four groups of mice, followed by an assessment of mean fluorescence intensity (MFI). The presented data depict the average and standard deviation from a minimum of three repetitions, with differences assessed using standard one-way ANOVA. *p < 0.05, **p < 0.01, ***p < 0.001