Fig. 1
Mitochondrial regulation of embryonic neurogenesis is modulated by the synergistic action of HIF1α, mTOR, and Wnt–(a) During embryonic and adult neurogenesis, changes in the metabolism of differentiating cells are accompanied by rearrangements of mitochondrial morphology. b NSCs' commitment to differentiation starts with a metabolic switch from glycolysis to OXPHOS inducing stem cells' asymmetric division and generating neuronal and glial progenitors. Differentiation may further proceed to neurons or oligodendrocytes/astrocytes. HIF1α together with the mTOR and the Wnt signaling are key modulators of these steps (Created with Biorender)