Fig. 3

Chromosome accessibility profile of HMrSV5 under different conditions. a Hierarchical clustering of ATAC-seq signals from the indicated samples. b Correlation analysis of ATAC-seq signals between the high glucose treatment group and the control group. Each dot represents one ATAC-seq peak. The values were normalized using the following formula: R/L × 10e9, where R represents the raw read count located in the peak and L represents the total read count of the ATAC-seq library. c, d Genomic distribution of ATAC-seq peaks in control HMrSV5 cells (c) and high glucose–treated HMrSV5 cells (d). ATAC-seq signals surrounding transcript start sites (TSSs)