Fig. 4

Adding TH to a cold preservation solution prevents prolonged cold preservation and warm reperfusion-induced expression of genes related to organ transplantation. Cells were treated with or without T3 (2.5 μM) or T4 (25 μM) during 18 h cold preservation, followed by 4 h warm reperfusion. Gene expression was assessed with NanoString. The pathways of gene expression were assessed with Gene Set Enrichment Analysis. A Compared to the control group, IR activated multiple gene pathways related to human organ transplantation. B, C T3 or T4 treatment downregulated human organ transplantation pathways