Fig. 3
From: PTEN deficiency potentiates HBV-associated liver cancer development through augmented GP73/GOLM1
Tumors in HBV; Pten−/− mice are mixed HCC-ICC. A H&E staining of livers from WT, HBV, Pten−/− and HBV; Pten−/− mice. B Masson’s trichrome and CD34 staining of 9-month-old WT, HBV, Pten−/−, and HBV; Pten−/− mouse livers. C Quantitation of Masson’s trichrome and CD34-positive area (n = 5). D Tgfb1 and Ctgf mRNA expression in 9-month-old WT, HBV, Pten−/−, and HBV; Pten−/− livers (n = 8–10). E H&E, Heppar-1 and CK19 staining of 9-month-old HBV; Pten.−/− livers. Scale bar, 100 μm. Data were shown as mean ± SD, *p < 0.05, **p < 0.01, ***p < 0.001