Fig. 2

Pten deficiency promotes liver tumor formation of HBV transgenic mice. A Immunoblotting analysis of the livers of WT mice and HBV transgenic mice. B Immunoblotting analysis of liver tumors and their adjacent liver tissues in HBV transgenic mice. T: tumor, N: adjacent non-tumor tissues. C Representative images of livers from WT, HBV, Pten^−/−, and HBV; Pten^−/− mice. D Tumor free of WT, HBV, Pten^−/−, and HBV; Pten^−/− mice (n = 21–25). E Ratio of liver weight to body weight for WT, HBV, Pten^−/−, and HBV; Pten^−/− mice with various ages (n = 3–6). F Number (> 3 mm) and G maximal size of liver tumors in 9-month-old Pten^−/− (n = 12), and HBV; Pten^−/− (n = 13) mice. H Survival of WT, HBV, Pten^−/−, and HBV; Pten.^−/− mice (n = 18–20). Data were shown as mean ± SD, *p < 0.05, **p < 0.01, ***p < 0.001