| Control | aPD-1 | Combination | F | P | Pa | ||
---|---|---|---|---|---|---|---|---|
Control vs aPD-1 | Control vs combination | aPD-1 vs combination | ||||||
Base | 185.800 ± 20.093 | 183.650 ± 17.526 | 189.000 ± 21.387 | 0.112 | 0.895 | NS | NS | NS |
3d | 344.467 ± 48.244 | 315.767 ± 33.637 | 303.867 ± 65.036 | 1.020 | 0.384 | NS | NS | NS |
6d | 642.533 ± 87.318 | 468.350 ± 89.289 | 318.733 ± 34.216 | 28.192 |  < 0.001 | 0.001 |  < 0.001 | 0.003 |
9d | 985.317 ± 77.350 | 472.850 ± 75.600 | 378.223 ± 45.691 | 139.303 |  < 0.001 |  < 0.001 |  < 0.001 | 0.029 |
12d | 1347.000 ± 69.155 | 583.100 ± 86.481 | 404.650 ± 32.692 | 338.346 |  < 0.001 |  < 0.001 |  < 0.001 |  < 0.001 |