Fig. 4

Multiple algorithms calculate the topological rank of each gene to determine the core gene based on the maximum overlap. A Protein–protein interaction (PPI) networks. B Multiple algorithms are used in Cytoscape to calculate the topological rank of each gene. C Various machine learning methods were employed, including Bayes, Decision Tree (DT), Fisher Discriminant Analysis (FDA), Gradient Boosting Machine (GBM), Neural Networks (NNET), Random Forest (RG), and XGBoost. D The area under curve (AUC) for all the above mentioned models