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Table 2 Multivariable linear regression to assess the association of vitamin B1 intake with cognitive function

From: Association between dietary vitamin B1 intake and cognitive function among older adults: a cross-sectional study

Variable

DSST

AFT

CERAD-IRT

CERAD-DRT

Z score

β (95% CI)

p-Value

β (95% CI)

p-Value

β (95% CI)

p-Value

β (95% CI)

p-Value

β (95% CI)

p-Value

 

Model 1

 

Model 1

 

Model 1

 

Model 1

 

Model 1

 

VB1 (mg/day)

1.84 (0.94 ~ 2.75)

 < 0.001

0.76 (0.47 ~ 1.05)

 < 0.001

0.17 (−0.08 ~ 0.41)

0.188

0.11 (−0.01 ~ 0.23)

0.082

0.08 (0.04 ~ 0.12)

 < 0.001

VB1 quartile

          

Q1 (≤ 0.97)

1(reference)

 

1(reference)

 

1(reference)

 

1(reference)

 

1(reference)

 

Q2 (0.98–1.33)

3.23 (1.32 ~ 5.14)

0.001

0.59 (−0.03 ~ 1.21)

0.062

0.15 (−0.37 ~ 0.67)

0.565

0.08 (−0.18 ~ 0.44)

0.532

0.09 (0.00 ~ 0.18)

0.041

Q3 (1.34–1.82)

3.49 (1.59 ~ 5.39)

 < 0.001

1.01 (0.39 ~ 1.62)

0.001

0.61 (0.10 ~ 1.13)

0.020

0.18 (−0.08 ~ 0.19)

0.168

0.15 (0.06 ~ 0.24)

0.001

Q4 (> 1.82)

4.40 (2.50 ~ 6.31)

 < 0.001

1.48 (0.86 ~ 2.10)

 < 0.001

0.25 (−0.28 ~ 0.75)

0.367

0.16 (−0.10 ~ 0.42)

0.224

0.16 (0.07 ~ 0.25)

 < 0.001

p for trend

 

 < 0.001

 

 < 0.001

 

0.159

 

0.164

 

 < 0.001

 

Model 2

 

Model 2

 

Model 2

 

Model 2

 

Model 2

 

VB1 (mg/day)

0.87 (0.17 ~ 1.56)

0.015

0.27 (−0.01 ~ 0.54)

0.055

0.22 (−0.01 ~ 0.45)

0.063

0.14 (0.02 ~ 0.25)

0.023

0.05 (0.02 ~ 0.09)

0.004

VB1 quartile

          

Q1 (≤ 0.97)

1(reference)

 

1(reference)

 

1(reference)

 

1(reference)

 

1(reference)

 

Q2 (0.98–1.33)

2.12 (0.71 ~ 3.52)

0.003

0.31 (−0.24 ~ 0.86)

0.275

0.06 (−0.41 ~ 0.53)

0.804

0.03 (−0.21 ~ 0.26)

0.811

0.05 (−0.02 ~ 0.12)

0.151

Q3 (1.34–1.82)

2.42 (1.01 ~ 3.83)

0.001

0.54 (−0.01 ~ 1.14)

0.055

0.65 (0.18 ~ 1.12)

0.007

0.20 (−0.04 ~ 0.43)

0.105

0.12 (0.05 ~ 0.19)

0.001

Q4 (> 1.82)

2.57 (1.11 ~ 4.02)

0.001

0.57 (−0.01 ~ 1.14)

0.053

0.33 (−0.15 ~ 0.82)

0.180

0.19 (−0.05 ~ 0.44)

0.125

0.10 (0.03 ~ 0.18)

0.006

p for trend

 

0.001

 

0.035

 

0.040

 

0.059

 

0.001

 

Model 3

 

Model 3

 

Model 3

 

Model 3

 

Model 3

 

VB1 (mg/day)

0.72 (0.03 ~ 1.41)

0.040

0.26 (−0.02 ~ 0.53)

0.065

0.20 (-0.03 ~ 0.43)

0.089

0.12 (0.01 ~ 0.24)

0.037

0.05 (0.01 ~ 0.08)

0.008

VB1 quartile

          

Q1 (≤ 0.97)

1(reference)

 

1(reference)

 

1(reference)

 

1(reference)

 

1(reference)

 

Q2 (0.98–1.33)

1.95 (0.57 ~ 3.34)

0.006

0.30 (−0.25 ~ 0.84)

0.291

0.04 (−0.43 ~ 0.51)

0.866

0.02 (−0.22 ~ 0.25)

0.884

0.05 (−0.02 ~ 0.12)

0.192

Q3 (1.34–1.82)

2.18 (0.79 ~ 3.57)

0.002

0.51 (−0.05 ~ 1.06)

0.073

0.62 (0.15 ~ 1.09)

0.010

0.18 (−0.06 ~ 0.42)

0.137

0.11 (0.04 ~ 0.18)

0.002

Q4 (> 1.82)

2.23 (0.79 ~ 3.67)

0.002

0.53 (−0.04 ~ 1.10)

0.067

0.28 (−0.20 ~ 0.77)

0.253

0.07 (−0.01 ~ 0.14)

0.198

0.09 (0.02 ~ 0.16)

0.015

p for trend

 

0.003

 

0.048

 

0.063

 

0.100

 

0.004

  1. CI confidence interval, VB1 vitamin B1, Q1-Q4 Quartile according to vitamin B1 intake, DSST Digit Symbol substation test, AFT Animal Fluency Test, CERAD Consortium to Establish a Registry for Alzheimer’s disease, CERAD-IRT immediate recall in CERAD trial, CERAD-DRT delayed recall in CERAD trial, Z score is average of the standardized scores of DSST, AFT, CERAD-IRT, CERAD-DRT; Model 1 was the crude model without adjustment for covariates. Model 2 was adjusted for age, gender, race/ethnicity, poverty income ratio, marital status, and education level. Model 3 was adjusted as for Model 2, additionally adjusted for body mass index, smoking status, alcohol status, hypertension, diabetes mellitus, cardiovascular disease history and stroke
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Journal of Translational Medicine

ISSN: 1479-5876

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