Table 1 Characteristics and genomic applications of tumors and their respective derived preclinical models
Pz code | Gender | Age at diagnosis (months) | Histopathologic classification of the tumor | INRG-SS Stage | Immunohistochemistry | Flow Cytometry | WES-g | WES-t | CGP | RNAseq | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
MYCN | CD45 | CD56 | TH | Phox-2B | S100 | CD45 | CD56 | GD2 | B7-H3 | NCL | yes (y) | yes (y) | yes (y) | yes (y) | |||||
pz#0 | M | 35 | NB, Schwannian-stroma poor, poorly differentiated | M | No ampl | + | + | + | + | − | NP | NP | NP | NP | NP | y | y | ||
pz#1 | M | 41 | NB, Schwannian-stroma poor, poorly differentiated | M | NP | + | + | + | + | NP | NP | NP | NP | NP | NP | y | |||
Pz#2 | F | 8 | NB, Schwannian-stroma poor, poorly differentiated | L2 | No ampl | + | + | + | + | NP | NP | NP | NP | NP | NP | y | y | y | |
Pz#2bis | No ampl | NP | NP | NP | NP | NP | − | + | NP | + | − | y | |||||||
Pz#3 | M | 46 | NB, Schwannian-stroma poor, undifferentiated | M | Ampl | + | + | + | + | + | + | + | + | + | + | y | y | y | |
PDX#3-P1 | NB, Schwannian-stroma poor, undifferentiated | Ampl | − | + | + | + | − | − | + | + | + | + | y | y | |||||
PDX#3-P2 | NB, Schwannian-stroma poor, undifferentiated | Ampl | − | + | + | + | − | − | + | + | + | + | y | y | |||||
PDX#3-P2-3D | NP | NP | NP | NP | NP | NP | − | + | + | + | NP | y | |||||||
Pz#4 | F | 198 | NB, Schwannian-stroma poor, undifferentiated | M | No ampl | + | + | + | − | NP | + | + | + | + | + | y | y | y | |
PDX#4-P1 | NB, Schwannian-stroma poor, undifferentiated | No ampl | − | + | + | − | − | − | + | + | + | + | y | y | |||||
PDX#4-P2 | NB, Schwannian-stroma poor, undifferentiated | No ampl | − | + | + | − | − | − | + | + | + | + | y | y | |||||
PDX#4-P2-3D | NP | NP | NP | NP | NP | NP | NP | NP | NP | NP | NP | y | |||||||
Pz#5 | M | 49 | NB, Schwannian-stroma poor, undifferentiated | M | No ampl GNE | + | NP | + | + | NP | NP | NP | NP | NP | NP | y | y | ||
PDX#5-P1 | NB, Schwannian-stroma poor, undifferentiated | No ampl GNE | − | + | + | + | − | NP | NP | NP | NP | NP | y | ||||||
PDX#5-P2 | NB, Schwannian-stroma poor, poorly differentiated | gain | − | + | + | + | − | − | + | + | + | + | y | ||||||
PDX#5-P2-3D | NP | NP | NP | NP | NP | NP | NP | NP | NP | NP | NP | ||||||||
Pz#6 | M | 45 | NE | L2 | No ampl | NP | NP | NP | NP | NP | NP | NP | NP | NP | NP | y | y | ||
Pz#7 | M | 172 | NB, Schwannian-stroma poor, undifferentiated | L1 | No ampl | + | + | + | ± | − | NP | NP | NP | NP | NP | y | y | y | |
Pz#8 | F | 89 | NB, Schwannian-stroma poor, undifferentiated | L2 | No ampl | ± | + | + | NE | − | + | + | + | + | + | y | y | y | |
PDX#8-P1 | NB, Schwannian-stroma poor, undifferentiated | No ampl | − | + | + | + | − | − | + | + | + | + | y | y | |||||
PDX#8-P2 | NB, Schwannian-stroma poor, undifferentiated | No ampl | − | + | + | + | − | − | + | + | + | + | y | ||||||
PDX#8-P2-3D | NP | NP | NP | NP | NP | NP | NP | NP | NP | NP | NP | y | |||||||
Pz#9 | M | 65 | NB, Schwannian-stroma poor, undifferentiated | M | No ampl | + | + | + | − | − | NP | NP | NP | NP | NP | y | y | ||
Pz#10 | F | 51 | NB, Schwannian-stroma poor, poorly differentiated | M | No ampl | + | + | + | + | − | NP | NP | NP | NP | NP | ^y (CGP) | y | ||
Pz#11 | F | 1 | NB, Schwannian-stroma poor, poorly differentiated | L1 | No ampl | + | + | + | ± | − | NP | NP | NP | NP | NP | y | y | y | |
Pz#14 | F | 101 | NB, Schwannian-stroma poor, poorly differentiated | L1 | No ampl | + | + | ± | + | − | NP | NP | NP | NP | NP | y | y | y | |
Pz#C | F | 22 | M | Ampl | NP | NP | NP | NP | NP | + | + | + | + | + | y | y | y | ||
Pz#C-3D | NP | NP | NP | NP | NP | NP | NP | NP | NP | NP | NP | ||||||||
CPDX#C-P1 | NB, Schwannian-stroma poor, undifferentiated | Ampl | − | + | + | + | − | − | + | + | + | ± | y | y | |||||
CPDX#C-P1-3D | NP | NP | NP | NP | NP | NP | − | + | + | + | + | ||||||||
CPDX#C-P2 | NB, Schwannian-stroma poor, undifferentiated | Ampl | − | + | + | + | − | − | + | + | + | ± | y | ||||||
CPDX#C-P2-3D | NP | NP | NP | NP | NP | NP | − | + | + | + | + | y | |||||||
Pz#D | M | 68 | M | NP | NP | NP | NP | NP | NP | + | + | + | + | + | y | y | |||
Pz#F | F | 39 | M | No ampl | NP | NP | NP | NP | NP | + | + | + | + | ± | y | y | |||
Pz#H | M | 39 | M | Gain | NP | NP | NP | NP | NP | + | + | + | + | ± | y | y | y | ||
Pz#I | F | 27 | M | Ampl | NP | NP | NP | NP | NP | + | + | + | + | ± | y | y | |||