Fig. 5

Tracking of potential therapeutically targetable somatic alterations among PDX or CPDX generations. A The figure shows the allele frequency of actionable pathogenic somatic variants detected in patient’s tumors and tracked in murine xenografts generations. B The figure shows the number of copies of actionable pathogenic somatic copy number variants detected in patient’s tumors and tracked in murine xenografts generations. Pz patient’s tumor, Pl first PDX generation, P2 second PDX generation, DEL Deletion; DUP Duplication, C Box plots showing the expression of gene levels of patient’s tumors and murine xenografts generations. The targetable gene showing an abnormal over-expression is reported in the red box